Alexander Xi Fu

About me

I’m a PhD student working on epigenomics and populational genetics and their application in disease risk prediction. Before starting my PhD study, I conducted research on Hirschsprung’s disease in CUHK CSE as an MPhil student and research assistant, during which I designed novel frameworks to utilize functional genomics data to prioritize noncoding disease-associated genetic variants. Find me on Twitter, Github and Linkedin.


  • 2020-Present, PhD in Biomedical Informatics, Columbia University
  • 2016-2019, MPhil in Computer Science and Engineering, The Chinese University of Hong Kong
  • 2012-2016, BSc in Cell and Molecular Biology, The Chinese University of Hong Kong

Research interests

  • Noncoding variants
  • Genetic diseases
  • Multi-omics


  • Fu, A.X., Lui, K.N.C., Tang, C.S.M., Ng, R.K., Lai, F.P.L., Lau, S.T., Li, Z., Gracia-Barcelo, M.M., Sham, P.C., Tam, P.K.H. and Ngan, E.S.W., 2020. Whole-genome analysis of noncoding genetic variations identifies multigranular regulatory element perturbations associated with Hirschsprung disease. Genome Research, gr.264473.120.
  • Cao, Q., Zhang, Z., Fu, A.X., Wu, Q., Lee, T.L., Lo, E., Cheng, A.S., Cheng, C., Leung, D. and Yip, K.Y., 2020. A unified framework for integrative study of heterogeneous gene regulatory mechanisms. Nature Machine Intelligence, pp.1-10.
  • Tang, C.S.M., Li, P., Lai, F.P.L., Fu, A.X., Lau, S.T., So, M.T., Lui, K.N.C., Li, Z., Zhuang, X., Yu, M. and Liu, X., 2018. Identification of genes associated with Hirschsprung disease, based on whole-genome sequence analysis, and potential effects on enteric nervous system development. Gastroenterology, 155(6), pp.1908-1922.
  • Gao, C., Zhuang, X., Cui, Y., Fu, X., He, Y., Zhao, Q., Zeng, Y., Shen, J., Luo, M. and Jiang, L., 2015. Dual roles of an Arabidopsis ESCRT component FREE1 in regulating vacuolar protein transport and autophagic degradation. Proceedings of the National Academy of Sciences, 112(6), pp.1886-1891.


  • Cooking
  • Photography
  • Calligraphy
  • Hiking

Author: Alexander Fu Xi

Created: 2020-09-21 Mon 14:53